Buy Avodart Online

What is Avodart?

Avodart (dutasteride) prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).

Avodart is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate. It helps improve urinary flow and may also reduce your need for prostate surgery later on.

Avodart is sometimes given with another medication called tamsulosin (Flomax). Be sure to read the medication guide or patient instructions provided with each of your medications.

Avodart may also be used for purposes not listed in this medication guide.

Important information about Avodart

Avodart should never be taken by a woman or a child. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle the capsules. Although Avodart is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Avodart capsules should not be handled by a woman who is pregnant or who may become pregnant.

Do not chew, crush, or open a Avodart capsule. Swallow the capsule whole. Dutasteride can irritate your lips, mouth, or throat if the capsule has been broken or opened before you swallow it. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away.

Before taking Avodart, tell your doctor if you have ever had an allergic reaction to dutasteride, or to a similar medicine called finasteride (Propecia, Proscar). Using Avodart may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using Avodart.

Do not donate blood while taking Avodart and for at least 6 months after your treatment ends. Avodart can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains dutasteride.

Before taking Avodart

Using Avodart may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using Avodart.

Before taking Avodart, tell your doctor if you have ever had an allergic reaction to this medication, or to a similar medicine called finasteride (Propecia, Proscar).

Avodart should never be taken by a woman or a child. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle Avodart capsules. Although this medicine is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Avodart capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away.

How should I take Avodart?

Take Avodart exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take the capsule with a full glass of water.

Avodart can be taken with or without food.

Do not chew, crush, or open a Avodart capsule. Swallow the capsule whole. Dutasteride can irritate your lips, mouth, or throat if the capsule has been broken or opened before you swallow it. It may take up to 6 months of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Do not stop taking Avodart without talking to your doctor.

To be sure this medication is helping your condition and not causing harmful effects, your blood may need to be tested often. Your doctor will also test your prostate specific antigen (PSA) to check for prostate cancer. Visit your doctor regularly.

Store Avodart at room temperature away from moisture and heat. The capsules may become soft and leaky, or they may stick together if they get too hot. Do not use any capsule that is cracked or leaking. Call your pharmacist for instructions on how to safely dispose of a leaking Avodart capsule.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Avodart?

Do not donate blood while taking Avodart and for at least 6 months after your treatment ends. Avodart can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains Avodart.

Avodart side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Avodart: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • decreased libido (sex drive);

  • decreased amount of semen released during sex;

  • impotence (trouble getting or keeping an erection); or

  • breast tenderness or enlargement.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Avodart?

Tell your doctor about all other medicines you use, especially:

  • conivaptan (Vaprisol);

  • imatinib (Gleevec);

  • isoniazid (for treating tuberculosis);

  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

  • an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

  • an antidepressant such as nefazodone;

  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G); or

  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra).

This list is not complete and other drugs may interact with Avodart. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

For the Consumer

Applies to dutasteride: oral capsule liquid filled

Along with its needed effects, dutasteride (the active ingredient contained in Avodart) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dutasteride:

Rare
  • Chest pain or discomfort
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • shortness of breath
  • swelling of the face, fingers, feet, or lower legs
  • weight gain
  • wheezing
Incidence not known
  • Blistering, flaking, or peeling of the skin
  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives or welts
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Some side effects of dutasteride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abnormal ejaculation
  • decreased interest in sexual intercourse
  • decreased sexual performance or desire
  • impotence
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • pain, soreness, swelling, or discharge from the breast or breasts

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Applies to dutasteride: oral capsule

General

In general, side effects have been mild and transient.

Genitourinary

The incidence of sexual adverse events has been reported to decrease with duration of treatment. After the first 6 months of treatment, the incidence of onset of impotence, decreased libido, ejaculation disorders, or gynecomastia was less than 1%. The adverse event profile for one two year study (n=677) reported that the onset of drug-related events was lower during the second year of treatment compared with the first , except for gynecomastia which was reported at 1% during the first year and 2 % during the second year.

Genitourinary side effects including impotence (up to 4.7%), decreased libido (up to 3.0%), ejaculation disorders (up to 1.4%), and gynecomastia (up to 1.1%) have been reported.

Postmarketing genitourinary side effects include testicular pain and swelling.

Hypersensitivity

Hypersensitivity side effects have been reported including allergic reactions such as angioedema, rash, pruritus, urticaria, and localized edema. Serious skin reactions have been reported during postmarketing experience.

Cardiovascular

In the CombAT study (to determine if combination therapy with dutasteride (the active ingredient contained in Avodart) and tamsulosin is more effective than either monotherapy alone), after 4 years of treatment, the incidence of the composite term cardiac failure in the combination therapy group (12/1,610; 0.7%) was higher than in either monotherapy group: Dutasteride, 2/1,623 (0.1%) and tamsulosin, 9/1,611 (0.6%). Composite cardiac failure was also examined in a separate 4-year placebo-controlled trial evaluating dutasteride in men at risk for development of prostate cancer. The incidence of cardiac failure in subjects taking dutasteride was 0.6% (26/4,105) compared to 0.4% (15/4,126) in subjects on placebo. A majority of subjects with cardiac failure in both studies had comorbidities associated with an increased risk of cardiac failure. Therefore, the clinical significance of the numerical imbalances in cardiac failure is unknown. No causal relationship between dutasteride, alone or in combination with tamsulosin, and cardiac failure has been established. No imbalance was observed in the incidence of overall cardiovascular adverse events in either study.

Oncologic

Postmarketing oncologic side effects have included male breast cancer.

Psychiatric

Postmarketing psychiatric side effects have included depressed mood.